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Corona im Fokus: HHU-Expertise zur Pandemie
SARS-CoV-2 kann das Zentrale Nervensystem befallen

Elektronenmikroskopaufnahme: SARS-CoV-2 Viren

SARS-CoV-2 Viren (grĘ╣n) besiedeln neuronale AuswĘ╣chse im Hirn-Organoiden. Copyright: J. Gopalakrishnan

In einer begutachteten Publikation in The EMBO Journal (2.9.2020) zeigt ein Forschungsteam um Prof. Jay Gopalakrishnan, Institut fĘ╣r Humangenetik, und Prof. Dr. Heiner Schaal, Institut fĘ╣r Virologie, beide Heinrich-Heine-Universit?t DĘ╣sseldorf (HHU) zusammen mit ╝¬¤Ú╗ó┬█╠│╣┘═°schaftler/innen aus Paris, K?ln, MĘ╣nster und Bonn, dass ein Isolat des Virus einen dreidimensionalen Organoiden des menschlichen Gehirns bef?llt, nachdem der Organoid dem Virus zwei Tage lange ausgesetzt war.

Das Laboratory for Centrosome and Cytoskeleton Biology des Instituts fĘ╣r Humangenetik, geleitet von Prof. Gopalakrishnan, entwickelt solche Hirn-Organoide, die man sich als ?Mini-Hirn in der Petrischaleí░ vorstellen muss. Sie dienen als Modelle fĘ╣r die menschliche Hirnentwicklung, die Entwicklung von Tumoren und Entwicklungsst?rungen.

Das Forscherteam erl?utert in der Publikation, dass SARS-CoV-2 die Zellk?rper von Nervenzellen der Hirnrinde bef?llt, nicht aber die neuronalen Stammzellen, wie es z.B. beim ZIKA Virus der Fall ist. Mit hochaufl?sender Bildgebung k?nnen die Autoren des Beitrags nach Exposition der Hirn-Organoide mit SARS-CoV-2 eine Misslokalisation des TAU Proteins vom Axon zum Soma (Nervenfaser zum Zellk?rper) zeigen sowie eine Hyperphosphorylierung des TAU Proteins, was vermutlich zum Zelltod fĘ╣hrt. TAU ist fĘ╣r die Stabilisierung der Nervenzellen wesentlich. Seine Fehlfunktion ist u.a. ein Kennzeichen der Alzheimer Krankheit.

Zudem co-lokalisiert das Virus Ę╣berraschenderweise mit dem krankheitsrelevanten TAU Protein, ein Indiz fĘ╣r frĘ╣he neuro-degenerative Effekte von SARS-CoV-2-positiven Nervenzellen. Die Studien liefern erste Einsichten in die Wirkung des Virus als ein neurotropisches Virus und zeigen zudem, dass Hirn-Organoiden als Modell fĘ╣r Erkrankungen des ZNS auch bei COVID-19 dienen k?nnen.

Originalpublikation: Anand Ramani, Lisa MĘ╣ller, Philipp Niklas Ostermann, Elke Gabriel, Pranty Abida-Islam, Andreas MĘ╣ller-Schiffmann, Aruljothi Mariappan, Olivier Goureau, Henning Gruell, Andreas Walker, Marcel AndrĘŽe, Sandra Hauka, Torsten Houwaart, Alexander Dilthey, Kai Wohlgemuth, Heymut Omran, Florian Klein, Dagmar Wieczorek, Ortwin Adams, J?rg Timm, Carsten Korth, Heiner Schaal, Jay Gopalakrishnan: SARSę\CoVę\2 targets neurons of 3D human brain organoids. EMBO J (2020)0:e2020106230, doi.org/10.15252/embj.2020106230

Kontakt:

Prof. Dr. Heiner Schaal, schaal@uni-duesseldorf.de, Institut fĘ╣r Virologie, Heinrich-Heine-Universit?t DĘ╣sseldorf, Tel.: +49-211 81-12393

Prof. Jay Gopalakrishnan Ph.D., jay.gopalakrishnan@hhu.de, Institut fĘ╣r Humangenetik, Heinrich-Heine-Universit?t, DĘ╣sseldorf, Tel: +49 211 81-11561

 

Die weltweite Ausbreitung des Coronavirus SARS-CoV-2 wirft zahlreiche Fragen nicht nur zu den gesundheitlichen, sondern auch zu wirtschaftlichen, rechtlichen und sozialen Folgen auf. Die ╝¬¤Ú╗ó┬█╠│╣┘═°schaft liefert hier entscheidende Fakten und Antworten. Viele Forscherinnen und Forscher der Heinrich-Heine-Universit?t DĘ╣sseldorf (HHU) aus unterschiedlichen Disziplinen sind durch ihre Arbeit aktuell gefragte Gespr?chspartner der Medien oder auch direkt in das Pandemie-Krisenmanagement eingebunden. Die HHU m?chte ihre wissenschaftliche Expertise in die ?ffentliche Diskussion einbringen, um so zur Einordnung und Bew?ltigung der Corona-Krise beizutragen.

Weitere Beitr?ge 'Corona im Fokus: HHU-Expertise zur Pandemie': Direkt zur ?bersichtsseite

 

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Kategorie/n: Schlagzeilen, Pressemeldungen, Forschung News, Corona-Expertisen
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